Like someone mentioned already, the biggest leap in odds of winning is buying that first line. After that you're odds go up so little that it's just about negligible. So, that's why the only real way to even noticably increase your odds is to have at least one play for every drawing. Don't spend $20 on one drawing. Spend $2 per drawing, but get it for the next 10 drawings. It's really the only way to maximize your odds. And NEVER get the multiplyer. It only helps with the lower amounts and with the possible exception of that payout just below the jackpot, it doesn't really help you much. That's a sucker option to increase jackpots quicker. Pay the lowest amount for one line and get it for every drawing. All 3 lottos I play only let me get 10 draws at a time. So, I get $10 of Lotto America, $20 of Powerball, and $20 of Mega Millions and I have one line for each lotto for 5 weeks
As for the numbers you get, it doesn't matter. It would be the same as being upset about only getting to pick heads or tails.... Still 50/50.
Fact is, I'll probably never win. But, I buy the ticket for the HOPE of it. That's why it's fun for me. I have a spreadsheet for each lotto (powerball, mega millions, and lotto America). I update the jackpot and I have all the tax figured into it so I can see instantly what I would get for all cash payout, annuity payout, and a split half cash/half annuity payout. Then on the bottom of the spreadsheet I have the formulas in there to see what's left after all of our debt is paid. I've pretty much decided that if we win, my wife and I will claim as dual winners and one of us will take the cash and one will take the annuity. That way we get a nice initial payout, but also get 30 years of guaranteed payouts.
Managing the spreadsheets is fun and I think and debate in my head how we would handle the money and which lotto would give us what ability to buy or invest. Which one do we get to both retire immediately with? That is what my $1 buys for me.