Do you use or have the "Bilt" app? It's a handy add-on and has the E6 instructions downloadable in it. I also downloaded the PDF instruction manual beforehand from the Weber site and practically had it memorized (yeah...I can go a bit overboard some times)!
Sorry, having the S6, no E6 model specific tips I can offer though.
One thing I am very happy I added (but everyone will have to decide based on how they cook etc.) was I ordered a second charcoal grate for the middle level. It was not expensive, and I found that we were doing lots of different cooks and it bugged me having to move the charcoal grate between the two levels repeatedly. Now I leave the bottom one in place (even if there is charcoal on it), and just add/remove the middle one when needed. It's a little thing, but I'm happy I did it. It also let's me use different drip pan options (even just a sheet of tin foil) on the middle layer when the charcoal is on the bottom without having the extra-wide coverage of the stainless steel deflector plate which for medium to high-heat indirect cooking I find blocks too much heat.