Sure. With enough exposure to any type of heat source (microwave, oven, gas grill, kettle, WSM), the ribs will get tender.
The reasons to wrap are to cut down cooking time, add flavors (butter, honey, brown sugar, etc.), limit smoke exposure, keep the ribs from getting too dark or too barky.
To keep it simple, I hang my ribs over the coals at 275F and never wrap. Cooks fast and come out tender. Also come out dark, smokey, barky.