Hi, Chris. Interesting thread. I haven't weighed in until now as the "tests" I've done in this area have been far from scientific. Then again, here's what I have seen....
The last cook I did had a 9lb whole brisket and 6lb chicken on the bottom grate, and a 6lb butt on the top grate. I had a 20" cake pan foiled and half full of sand. The top grate ran at 255-260 and the bottom grate ran at 240-245. I took the chicken out when it was done (lunch) and re-assembled the cooker, same differentials with the bottom grate about 10* lower then the top.
The cook I did before that one, I had two 7 lb butts on the bottom and four slabs of spares on the top. I had intended to use sand, but didn't have any, so I decided to just go with the empty pan foiled. My temps tended to jump around a little bit more than when I use sand, but I was still holding the cooker in my targeted 220-245 range. In this case, though, the top grate was running about 10-12* hotter than the bottom grate.
The only caveat to all of this is, I'm not using a WSM, but a modified Weber kettle. All-in-all, though, I would imagine that it operates about the same as a WSM does.
Hope this helps.
Rich G.