Dan,
I would eliminate the variable of using different kinds of charcoal and focus on just one until you get this sorted out. I would suggest Kingsford Blue since it burns longer than Kingsford competition and is more consistent than lump.
Re: Dave's comment of "therm issue", he just means an inaccurate thermometer. As I mentioned in my previous post, some have complained about the accuracy of the thermometers Weber's using. I would recommend you test it as I described so you can eliminate that as a variable.
You did not mention what kind of charcoal chimney you are using. Weber's chimney has greater capacity than most--about 6 quarts or 100 briquets. If you're using another brand, you may be starting with 20% less charcoal than people using a Weber chimney.
You mentioned that you cook in warm temps, about 80*F or higher ambient temperature. Is it windy where your cooker is situated? Wind can suck the heat right out of these metal cookers. If so, move to a protected location or create some sort of wind break.
Re: Your question about shutting the vents more than 50%, the point of opening or closing vents is to regulate temperature so the cooker runs at the temp you want. So if you've got them set at 50% and it runs at 225-250*F for up to 4 hours, that's a good thing. If you shut them more, the temp would drop. If you open them more, the temp should increase. So I think the answer to your question is "no".
Just so we're not taking anything for granted...now moving into less common territory...Do you have the lid vent 100% open during the entire cook? Do you have the water pan sitting on the bottom flanges in the middle cooking section? Please don't be offended, but we've had people place the water pan right on top of the charcoal chamber, in direct contact with the coals, which of course smothers the fire.
Even celebrity chefs can make this mistake.
If we determine that your thermometer is accurate to within +/-5*F and you don't have the water pan sitting directly on the charcoal
, then I have to think you're just not using enough charcoal to begin with. The 22.5" is a big cooker and it takes a lot more fuel to bring it up to temp than with the 18.5", and even though you're cooking very little (ie a single turkey breast or a single pork shoulder) it's going to take a lot of fuel to keep that big cooker going at 250*F for 8 hours.
One test you can try, since Kingsford Blue is pretty cheap, is to just fill that charcoal chamber all the way to the top, then pour that 1/2 chimney of unlit on top. Add your meat and water, open those bottom vents 100%. Don't worry too much about how long it takes to come up to 250*F. Adjust your bottom vents to 50% in order to maintain 250*F. Keep that top vent wide open. See how long it will run at 250...it should be more than 4 hours.
The long cooks you're hearing about do exist. We've just got to keep eliminating variables until we help you figure it out.
Regards,
Chris