I don't pull the meat off in many cases. Depends on the size of the meat cut. Nor do I necessarily crank the temps up. Searing doesn't necessarily require high kettle temps, just a hot enough direct situation. Often I just leave the meat alone and rotate the grate so that the meat is direct.
In terms of enzymatic activity, searing to finish is beneficial on cuts that are normally on the tough side whether steaks or roasts. It can be used, though, with tender steaks and roasts. Enzymatic activity is not that important with these, but searing to finish thicker steaks or large roasts cuts - beef tenderloin, say, or strip loin roasts - can offer the cook some flexibility. It enables him or her to cook moderately at the outset an attend to other things, dealing the the finishing sear at the end of the cook, in just a few minutes.