I ususally trim out the shoulder for marinated steaks or stir fry, eliminating all of the silver and tendon nastiness. I've prepared venison rump roast like pot roast in the past with good results.
I imagine you could approach it like a pork butt. A cut like this would probably benefit from a low and slow effort if you're cooking it whole. I would also consider foiling after a couple of hours to lock in moisture.......there is not a lot of fat embedded to render and flavor the meat.
Good luck and let us know how it turns out!!