Are you cooking until fall-apart tender so you can shred the meat? If so, you're going to take it to 200°F and then see if it's fork tender and shreds, but keep cooking if it's not.
Once you get to around 160 IT, you can put the roast in a disposable pan wit either beef broth or beer and some onion and green pepper. Cover and smoke for 2 more hours. Uncover, shred and smoke for another hour to meld the beef and liquid.