B, I have drilled new vent holes in both my 18 & 22. Drilling a therm hole should be easier since the hole is smaller. I would tape the spot where you want the hole with blue or green painters tape. Next get a small punch, hold it on the tape and gently wack it with a small hammer. Next get a small drill bit that is very sharp and drill a hole thru the lide in the spot that you dented with your punch. After you make the first small hole use the correct size drill bit to make the hole as large as the therm stem. After you are done you may have to smooth the edges on the underside a bit with course sand paper, or not.
As far as putting a Weber therm on the lid, I would think twice about that choice. I believe from my experience and others here that there are far superior therms that can be used. Search the site for therms.
Mark