If you end up doing the lo n slo overnight method (my choice), you may want to consider wrapping in foil as the internal meat temp approaches the 150-160* range. Adding an au jus type liquid in the foil helps break down muscle fiber to tenderize while remaining moist. Pull at 195-202* and let it rest.
As a side note: I have put the brisket in an alum steam pan partially filled with au jus liquid, and covered with foil. I do this at the foiling stage. This keeps from leaking which foil packs always seem to do for me!