When I'm in Las Vegas or Shawnee I do them that way all the time as I do not have a smoker in either location.
I do them the same way as I do them in a WSM, at high heat, but since it's a kettle I do two piles of coals, in the holders, unlit, and top each with maybe 4 lit. When I set up the coal holders I place them on a piece of foil, one piece each, fill with unlit, top with wood and lit or lit and pellet packets, then bring the foil up and somewhat over the coals (I though I had a pic somewhere but can't find it) so the heat is deflected and the brisket in not exposed to direct heat.
I shoot for ~350, cook ~2.5 hours, foil the brisket, then cook till tender, about 1.5 hours more. Rest 25 min, tented, slice and serve.