Paul,
Many members here feel mesquite is for grilling and not for smoking. I have used apple, cherry, and hickory and loved them all equally.
Mesquite may be too bitter for a smoke. It's also one the those flavors, that either you love it or you hate it. Mild fruit woods appeal to the masses. My family hated mesquite, which I love for grilling, and decided that meant they hated all smoked foods. Then I made the BRITU with fruit woods and they absolutely love it.
Good luck, I hope this helped.