I smoked a meat loaf (acutally a venison loaf) for the first time this weekend on the WSM. For smoke wood I used two fist sized pieces of cherry wood. I used no water in the pan and ran the smoker for about an hour and half at 350 - 375 degrees. I took the loaf off at 170 degrees internal temp. I also put the meat loaf on wax paper durning the cook so the smoke could reach all the way around the loaf. The meatloaf was awesome! Nice smoke ring and the smoke flavor really adds a lot the meat loaf. I was thinking next time to rub the loaf with some rub before smoking it to really kick it up a notch. The only problem I ran into was the loaf kind of fell apart when we were slicing it. But, I think that was because I did not use enough eggs or breadcrumbs in my recipe, not because of the WSM cook. Smoked meatloaf is a must try for anyone who has not already! Can't wait to eat my meatloaf sandwich for lunch.