<BLOCKQUOTE class="ip-ubbcode-quote"><div class="ip-ubbcode-quote-title">quote:</div><div class="ip-ubbcode-quote-content">You can rub the meat in advance if you wish but I see no need to at all. </div></BLOCKQUOTE>I like the double rub esp for big cuts like that. Rub say 12 hours in advance or overnight, rub again before smoking. It seems to cause good flavor penetration.
I agree with cutting in half, if you don't it takes too long and not enough surface area for smoke as well as rub. If you don't when you mix it all up it doesn't have a strong BBQ taste ... just beef. Tried cutting one into quarters ... it was a bad cook but that seemed a little too much, I think halves was better.
Do cook it enough, don't just use temp. Make sure it is nice and tender and will pull easily before you stop cooking it. Similar to another thread right now about greasy pork I found my first chuck extremely greasy and difficult to pull: it just wasn't cooked long enough.
I'd suggest sticking to 250ºF or perhaps even as high as 300ºF (I have yet to try that high but I'm gonna) until you get to around 165ºF internal, then double foil and in the oven at 275ºF until tender. Main point is experience has shown me 225ºF just isn't hot enough to do a decent job .. it can get dry before it gets tender.